The Journal of Infectious Diseases · 2022 · 23 citations · 12 references
Veterinary MedicineImmunologyInfectious DiseasesImmunizationVaccine ImmunologyVaccinologyAdult ImmunizationVaccinationVaccine EffectivenessVaccine EfficacyVaccine SafetyViral VaccinesClinical Utility AnalysisClinical Utility AssessmentCoronavirus VaccinesMessenger Rna (Mrna) VaccinesObservational Study AnalysisSars-cov-2 InfectionSerologic Response To Booster VaccinationSevere Acute Respiratory Syndrome
The relationship between antibodies to wild-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens and the risk of breakthrough infections is unclear, especially during circulation of the Omicron strain. We investigated the association of anti-spike and anti-receptor binding domain antibody levels and the risk of subsequent breakthrough coronavirus disease 2019 (COVID-19). We included adult paramedics from an observational cohort study who received 2 mRNA vaccines but did not have COVID-19 before the blood collection. Higher postvaccination antibody levels to wild-type SARS-CoV-2 antigens were associated with a reduced risk of COVID-19. Further research into clinical utility of antibody levels, to inform a threshold for protection and timing of boosters, should be prioritized.
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Covid-19 Breakthrough Infections in Vaccinated Health Care Workers
Moriah Bergwerk, Tal Gonen, Yaniv Lustig et al. · New England Journal of Medicine · 2021 · 1.5K citations · Full text
Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection
Shuo Feng, Daniel J. Phillips, Thomas White et al. · Nature Medicine · 2021 · 1.2K citations · Full text