Phenocopies of poor metabolizers of omeprazole caused by liver disease and drug treatment

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.

S.M. de Morais, G. Wilkinson, Joyce Blaisdell et al. · Journal of Biological Chemistry · 1994 · 952 citations · Full text

Medicine, Genetics, Pharmacology +17

Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPase

E. Fellenius, T. Berglindh, George Sachs et al. · Nature · 1981 · 625 citations

Medicine, Biochemistry, Pharmacology +10

Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9

Allan E. Rettie, Larry C. Wienkers, Frank J. Gonzalez et al. · Pharmacogenetics · 1994 · 493 citations

Medicine, Molecular Genetics, Pharmacology +10

Evidence That CYP2C19 is the Major (S)-Mephenytoin 4'-Hydroxylase in Humans

Jorge Goldstein, M B Faletto, M Romkes-Sparks et al. · Biochemistry · 1994 · 363 citations

Medicine, Biochemistry, Pharmacology +10

Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450

Dominique Diaz, Isabelle Fabrev, Martine Daujat‐Chavanieu et al. · Gastroenterology · 1990 · 311 citations

Medicine, Pharmacokinetics, Pharmacology +14