Prostate Cancer in Nigerians: Facts and Nonfacts

Abstract

No AccessJournal of UrologyClinical Urology: Original Article1 Apr 1997Prostate Cancer in Nigerians: Facts and Nonfacts D.N. Osegbe D.N. OsegbeD.N. Osegbe View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64966-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We established the actual incidence of prostate cancer in Nigeria, the largest concentration of indigenous black patient in the world, to ascertain whether the global ranking for Nigeria as a low risk for prostate cancer is accurate. Materials and Methods: We prospectively studied Nigerian men 45 years old or older with prostatic symptoms. Patients histologically positive for prostate cancer were analyzed for clinical features, tumor characteristics and survival. The hospital incidence, national prostate cancer risk, pool and death rate were calculated from the hospital admissions data and national population statistics. Results: Mean age of patients with prostate cancer plus or minus standard deviation was 68.3 +/− 9.4 years. The hospital incidence was 127/100,000 cases. The national prostate cancer risk was 2% of patients, the pool was 110,000 and the death rate was 20,000 annually. The predominant clinical findings were those of advanced disease. Approximately 64% of the patients died within 2 years. Conclusions: Prostate cancer incidence and the magnitude of the risk in our population may have been grossly underestimated. The clinical prostate cancer rate in Nigerians may be as great as that noted in black men in the United States, which may suggest a common genetic predisposition. References 1 : Epidemiology of cancer of the prostate. Cancer1971; 28: 344. Google Scholar 2 : Cancer of the prostate: epidemiology and aetiology. Brit. J. Urol.1987; 59: 493. Google Scholar 3 : Characterization of prostatic carcinoma amongst blacks. A continuation report. Cancer. Treat. Rep.1977; 61: 167. Google Scholar 4 : Blood hormone profiles in prostate cancer patients in high risk and low risk population. Cancer1981; 48: 2267. Google Scholar 5 : Androgen concentration in blacks with benign and malignant prostatic disease. J. Urol.1981; 140: 160. Google Scholar 6 : Cancer in the European Community and its member states. Eur. J. Cancer1990; 26: 1167. Google Scholar 7 : Prostate cancer detection in a clinical urological practice by ultrasonography, digital rectal examination and prostate specific antigen. J. Urol.1990; 143: 1146. Link, Google Scholar 8 : Current strategies in hormonal manipulation of advanced prostatic cancer. Curr. Opin. Urol.1991; 1: 16. Google Scholar 9 : Adenocarcinoma of the prostate in a 41-year-old man with XXY karyotype and chronic lymphocytic leukaemia: report of a case. J. Urol.1991; 145: 148. Google Scholar 10 : Prostate-specific antigen values at the time of prostate cancer diagnosis in African-American men. J.A.M.A.1995; 274: 1277. Crossref, Medline, Google Scholar 11 : Race, treatment and longterm survival from prostate cancer in an equal-access medical care delivery system. J.A.M.A.1995; 274: 1599. Google Scholar 12 : The role of increasing detection in the rising incidence of prostate cancer. J.A.M.A.1995; 273: 548. Google Scholar 13 : Cancer statistics. CA1995; 45: 127. Google Scholar 14 : Cancer statistics. CA1994; 44: 7. Google Scholar 15 : Diagnostic significance of prostate specific antigen and the development of a mass screening system for prostate cancer. J. Urol.1995; 154: 1085. Link, Google Scholar 16 : Prostate cancer: comparison of digital rectal examination and transrectal ultrasound for screening. J. Urol.1991; 145: 86. Link, Google Scholar 17 : Cadmium and prostatic carcinoma. Lancet1967; 1: 730. Google Scholar 18 : Zinc and cadmium concentrations in indigenous blacks with normal, hypertrophic and malignant prostate. Cancer1989; 63: 1388. Google Scholar 19 : Family history and the risk of prostate cancer. Prostate1990; 17: 337. Crossref, Medline, Google Scholar 20 : Familial pattern of prostate cancer: a case-control analysis. J. Urol.1991; 146: 1305. Abstract, Google Scholar 21 : Carcinoma of bladder and urethra in patients with urethral stricture. East Afr. Med. J.1975; 52: 12. Google Scholar 22 : Screening for carcinoma of the prostate by digital rectal examination in a randomly selected population. Brit. Med. J.1990; 300: 1041. Google Scholar 23 : Identification of residual cancer in the prostate following radiation therapy: role of transrectal ultrasound guided biopsy and prostate specific antigen. J. Urol.1989; 142: 326. Link, Google Scholar 24 : Trends in patterns of care for prostatic cancer 1974-1983; result of survey by the American College of Surgeons. J. Urol.1986; 136: 416. Abstract, Google Scholar 25 : Primary orchiectomy versus estrogen therapy in advanced prostatic cancer-a randomized study: results after 7 to 10 years of followup. J. Urol.1991; 145: 519. Link, Google Scholar 26 : The prognostic value of deoxyribonucleic acid flow cytometric analysis in stage D2 prostatic carcinoma. J. Urol.1991; 145: 1192. Link, Google Scholar 27 : Orchidectomy for advanced prostatic cancer: a reevaluation. Urology1973; 1: 553. Google Scholar From the Urology Unit, Department of Surgery, College of Medicine and Lagos University Teaching Hospital, Lagos, Nigeria© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byGLOVER F, COFFEY D, DOUGLAS L, CADOGAN M, RUSSELL H, TULLOCH T, BAKER T, WAN R and WALSH P (2018) THE EPIDEMIOLOGY OF PROSTATE CANCER IN JAMAICAJournal of Urology, VOL. 159, NO. 6, (1984-1987), Online publication date: 1-Jun-1998. Volume 157Issue 4April 1997Page: 1340-1343 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information D.N. Osegbe More articles by this author Expand All Advertisement PDF downloadLoading ...