UNC Libraries · 2020 · 11 citations · 0 references
Life SciencesGeneticsOncologyCancer GeneticsComparative GenomicsGenomicsCancer GenomicsCancer TranscriptomicsComparative Cancer GeneticsNext-generation Sequencing In OncologySquamous Cell CarcinomaComparative Somatic Mutation AnalysisCopy Number Alteration AnalysisExome Copy Number AnalysisLung Squamous Cell CarcinomaMutational Spectrum AnalysisSomatic Genomic AlterationsSomatic Mutation AnalysisTranscriptome Analysis
Lung squamous cell carcinoma (SCC) is the second most prevalent type of lung cancer. Currently, no targeted therapeutics are approved for treatment of this cancer, largely because of a lack of systematic understanding of the molecular pathogenesis of the disease. To identify therapeutic targets and perform comparative analyses of lung SCC, we probed somatic genome alterations of lung SCC by using samples from Korean patients.