Value of Systematic Transition Zone Biopsies in the Early Detection of Prostate Cancer

Abstract

No AccessJournal of UrologyClinical Urology: Original Article1 Feb 1996Value of Systematic Transition Zone Biopsies in the Early Detection of Prostate Cancer Michel Bazinet, Pierre I. Karakiewicz, Armen G. Aprikian, Claude Trudel, Samuel Aronson, Mahmoud Nachabe, Francois Peloquin, Jean Dessureault, Michelle Goyal, Wei Zheng, Louis R. Begin, and Mostafa M. Elhilali Michel BazinetMichel Bazinet More articles by this author , Pierre I. KarakiewiczPierre I. Karakiewicz More articles by this author , Armen G. AprikianArmen G. Aprikian More articles by this author , Claude TrudelClaude Trudel More articles by this author , Samuel AronsonSamuel Aronson More articles by this author , Mahmoud NachabeMahmoud Nachabe More articles by this author , Francois PeloquinFrancois Peloquin More articles by this author , Jean DessureaultJean Dessureault More articles by this author , Michelle GoyalMichelle Goyal More articles by this author , Wei ZhengWei Zheng More articles by this author , Louis R. BeginLouis R. Begin More articles by this author , and Mostafa M. ElhilaliMostafa M. Elhilali More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66463-2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: A prospective study was done to determine the value of performing 2 systematic transition zone biopsies in addition to systematic sextant peripheral zone biopsies for early detection of prostate cancer. Materials and Methods: From January 1 to August 31, 1994 we evaluated 847 consecutive patients referred to us for a suspicious lesion on digital rectal examination or an elevated serum prostate specific antigen level. All patients underwent 2 systematic transition zone biopsies in addition to systematic sextant biopsies of the peripheral zone. Results: Of the transition zone biopsies 68 (24.4 percent) contained malignancy, including only 8 (2.9 percent) with cancer found exclusively in the transition zone. The remaining 271 cases (97.1 percent) had 1 or more positive peripheral zone biopsies and would have been detected with or without additional systematic transition zone biopsies. The same analysis of 552 patients with a negative digital rectal examination yielded 6 (4.1 percent) exclusively transition zone tumors among 145 cancers detected in this group. Conclusions: The low additional yield of transition one biopsies (2.9 to 4.1 percent) does not warrant their systematic use for the early detection of prostate cancer. References 1 : Influence of patient age on the serum PSA concentration. An important clinical observation. Urol. Clin. N. Amer.1993; 20: 671. Google Scholar 2 : Prospective evaluation of prostate-specific antigen density and systematic biopsies for early detection of prostatic carcinoma. 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Link, Google Scholar UROMED Prostate Cancer Detection Center and Departments of Urology and Pathology, McGill University, Montreal, Quebec, Canada.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byBjurlin M, Carter H, Schellhammer P, Cookson M, Gomella L, Troyer D, Wheeler T, Schlossberg S, Penson D and Taneja S (2013) Optimization of Initial Prostate Biopsy in Clinical Practice: Sampling, Labeling and Specimen ProcessingJournal of Urology, VOL. 189, NO. 6, (2039-2046), Online publication date: 1-Jun-2013.Haarer C, Gopalan A, Tickoo S, Scardino P, Eastham J, Reuter V and Fine S (2009) Prostatic Transition Zone Directed Needle Biopsies Uncommonly Sample Clinically Relevant Transition Zone TumorsJournal of Urology, VOL. 182, NO. 4, (1337-1341), Online publication date: 1-Oct-2009.SINGH H, CANTO E, SHARIAT S, KADMON D, MILES B, WHEELER T and SLAWIN K (2018) Predictors of Prostate Cancer After Initial Negative Systematic 12 Core BiopsyJournal of Urology, VOL. 171, NO. 5, (1850-1854), Online publication date: 1-May-2004.MATLAGA B, ESKEW L and McCULLOUGH D (2018) Prostate Biopsy: Indications and TechniqueJournal of Urology, VOL. 169, NO. 1, (12-19), Online publication date: 1-Jan-2003.DAVIS M, SOFER M, KIM S and SOLOWAY M (2018) THE PROCEDURE OF TRANSRECTAL ULTRASOUND GUIDED BIOPSY OF THE PROSTATE: A SURVEY OF PATIENT PREPARATION AND BIOPSY TECHNIQUEJournal of Urology, VOL. 167, NO. 2 Part 1, (566-570), Online publication date: 1-Feb-2002.EMILIOZZI P, LONGHI S, SCARPONE P, PANSADORO A, DePAULA F and PANSADORO V (2018) THE VALUE OF A SINGLE BIOPSY WITH 12 TRANSPERINEAL CORES FOR DETECTING PROSTATE CANCER IN PATIENTS WITH ELEVATED PROSTATE SPECIFIC ANTIGENJournal of Urology, VOL. 166, NO. 3, (845-850), Online publication date: 1-Sep-2001.BABAIAN R, TOI A, KAMOI K, TRONCOSO P, SWEET J, EVANS R, JOHNSTON D and CHEN M (2018) A COMPARATIVE ANALYSIS OF SEXTANT AND AN EXTENDED 11-CORE MULTISITE DIRECTED BIOPSY STRATEGYJournal of Urology, VOL. 163, NO. 1, (152-157), Online publication date: 1-Jan-2000.FOWLER J, BIGLER S and KOLSKI J (2018) PROSTATE CANCER DETECTION IN CANDIDATES FOR OPEN PROSTATECTOMYJournal of Urology, VOL. 160, NO. 6 Part 1, (2107-2110), Online publication date: 1-Dec-1998.Chen M, Troncoso P, Johnston D, Tang K and Babaian J (2018) OPTIMIZATION OF PROSTATE BIOPSY STRATEGY USING COMPUTER BASED ANALYSISJournal of Urology, VOL. 158, NO. 6, (2168-2175), Online publication date: 1-Dec-1997.Epstein J, Walsh P, Sauvageot J and Ballentine Carter H (2018) USE OF REPEAT SEXTANT AND TRANSITION ZONE BIOPSIES FOR ASSESSING EXTENT OF PROSTATE CANCERJournal of Urology, VOL. 158, NO. 5, (1886-1890), Online publication date: 1-Nov-1997.Plawker M, Fleisher J, Vapnek E and Macchia R (2018) CURRENT TRENDS IN PROSTATE CANCER DIAGNOSIS AND STAGING AMONG UNITED STATES UROLOGISTSJournal of Urology, VOL. 158, NO. 5, (1853-1858), Online publication date: 1-Nov-1997.Rovner E, Schanne F, Malkowicz B and Wein A (2018) Transurethral Biopsy of the Prostate for Persistently Elevated or Increasing Prostate Specific Antigen Following Multiple Negative Transrectal BiopsiesJournal of Urology, VOL. 158, NO. 1, (138-142), Online publication date: 1-Jul-1997.Ornstein D, Rao G, Smith D and Andriole G (2018) The Impact of Systematic Prostate Biopsy on Prostate Cancer Incidence in Men With Symptomatic Benign Prostatic Hyperplasia Undergoing Transurethral Resection of the ProstateJournal of Urology, VOL. 157, NO. 3, (880-884), Online publication date: 1-Mar-1997.Fleshner N and Fair W (2018) Indications for Transition Zone Biopsy in the Detection of Prostatic CarcinomaJournal of Urology, VOL. 157, NO. 2, (556-558), Online publication date: 1-Feb-1997.Terris M, Pham T, Issa M and Kabalin J (2018) Routine Transition Zone and Seminal Vesicle Biopsies in All Patients Undergoing Transrectal Ultrasound Guided Prostate Biopsies are Not IndicatedJournal of Urology, VOL. 157, NO. 1, (204-206), Online publication date: 1-Jan-1997. Volume 155Issue 2February 1996Page: 605-606 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Michel Bazinet More articles by this author Pierre I. Karakiewicz More articles by this author Armen G. Aprikian More articles by this author Claude Trudel More articles by this author Samuel Aronson More articles by this author Mahmoud Nachabe More articles by this author Francois Peloquin More articles by this author Jean Dessureault More articles by this author Michelle Goyal More articles by this author Wei Zheng More articles by this author Louis R. Begin More articles by this author Mostafa M. Elhilali More articles by this author Expand All Advertisement PDF downloadLoading ...