Activation of Piezo1 contributes to matrix stiffness‐induced angiogenesis in hepatocellular carcinoma

Abstract

This study unravels a new mechanism by which the integrin β1/Piezo1 activation/Ca²⁺ influx/HIF-1α ubiquitination/VEGF, CXCL16 and IGFBP2 pathway participates in matrix stiffness-driven HCC angiogenesis. Simultaneously, a positive feedback regulation loop as stiff matrix/integrin β1/miR-625-5p/Piezo1 and COL1/stiffer matrix mediates matrix stiffness-caused Piezo1 upregulation.