Do Human Papillomaviruses Have a Role in the Pathogenesis of Bladder Carcinoma?

Abstract

No AccessJournal of UrologyClinical Urology: Original Article1 Feb 1996Do Human Papillomaviruses Have a Role in the Pathogenesis of Bladder Carcinoma? Mansuka Mvula, Tsuyoshi Iwasaka, Atsushi Iguchi, Satoru Nakamura, Zenjiro Masaki, and Hajime Sugimori Mansuka MvulaMansuka Mvula , Tsuyoshi IwasakaTsuyoshi Iwasaka , Atsushi IguchiAtsushi Iguchi , Satoru NakamuraSatoru Nakamura , Zenjiro MasakiZenjiro Masaki , and Hajime SugimoriHajime Sugimori View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66421-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Since little is known of the associations between bladder carcinoma and human papillomaviruses (HPVs), data on the role of HPV in bladder carcinogenesis are controversial. We attempted to clarify whether HPVs are present in bladder carcinomas. Materials and Methods: We examined 36 specimens of bladder carcinoma for HPV positivity by the polymerase chain reaction method. Results: HPV-16 deoxyribonucleic acid was detected in 1 specimen (3 percent) of a transitional cell carcinoma from a 37-year-old woman who had concomitant squamous cell carcinoma of the uterine cervix with positive para-aortic lymph node metastasis. The cervical tumor, bladder tumor and para-aortic lymph node metastasis were all positive for the same type of HPV. Conclusions: On the basis of this low rate of HPV detection (3 percent), HPVs are not likely to have a prominent role in carcinogenesis of the bladder. References 1 : Demonstration of papillomavirus structural antigen in human urinary bladder neoplasia. Brit. J. Urol.1987; 60: 405. Google Scholar 2 : Squamous cell carcinoma of the bladder following radiotherapy for transitional cell carcinoma. Brit. J. Urol.1994; 74: 131. Google Scholar 3 : . St. Louis: C. V. Mosby, Co.1989: 904. Google Scholar 4 : Papillomaviruses in anogenital cancer as a model to understand the role of viruses in human cancers. Cancer Res.1989; 49: 4677. Google Scholar 5 : Oncogenic human papillomaviruses are rarely associated with squamous cell carcinoma of the bladder: evaluation by differential polymerase chain reaction. J. Urol.1994; 151: 360. Abstract, Google Scholar 6 : Oncogenic human papillomavirus type 16 is associated with squamous cell cancer of the male urethra. Cancer Res.1992; 52: 5018. Google Scholar 7 : Low incidence of human papillomavirus type 16 DNA in bladder tumor detected by the polymerase chain reaction. Cancer1992; 69: 1208. Google Scholar 8 : Polymerase chain reaction used in the detection of human papillomavirus in transitional cell cancer. J. Urol., part 21991; 145: 430A. abstract 872. Google Scholar 9 : Human papillomavirus sequences are not detectable by Southern blotting or general primer-mediated polymerase chain reaction in transitional cell tumors of the bladder. Urol. Res.1992; 20: 297. Google Scholar 10 : Transitional cell carcinoma of the bladder: failure to demonstrate human papillomavirus deoxyribonucleic acid by in situ hybridization and polymerase chain reaction. J. Urol.1994; 152: 1429. Abstract, Google Scholar 11 : Human papillomavirus types 16 and 18 association with invasive human bladder tumor. J. Urol., part 21991; 145: 311A. abstract 396. Google Scholar 12 : Detection of human papillomavirus genome and analysis of expression of c-myc and Ha-ras oncogenes in invasive cervical carcinomas. Gynec. Oncol.1992; 46: 298. Google Scholar 13 : Avoiding false positives with PCR. Nature1989; 339: 237. Google Scholar 14 : Detection and typing of multiple genital human papillomaviruses by DNA amplification with consensus primers. Jap. J. Cancer, Res.1991; 82: 524. Google Scholar 15 : Transitional cell carcinoma of the bladder in young adults. Brit. J. Urol.1993; 72: 749. part 2. Google Scholar 16 : High prevalence of human papillomavirus in prostate tissues. J. Urol.1991; 145: 850. Link, Google Scholar 17 : Condyloma acuminatum of bladder. Urology1981; 17: 381. Google Scholar 18 : High frequency of human papillomavirus infection in carcinoma of the urinary bladder. Cancer1992; 70: 1967. Google Scholar 19 : Presence of human papillomavirus type 16 genome in bladder carcinoma in situ of a patient with mild immunodeficiency. Cancer Res.1988; 48: 7207. Google Scholar 20 : Detection of human papillomavirus DNA in cancer of the urinary bladder by in situ hybridisation. Brit. J. Urol.1991; 68: 49. Google Scholar 21 : Human papillomavirus associated with bladder cancer. Urology1992; 40: 15. Google Scholar 22 : Transitional cell carcinoma of the bladder: evaluation of the role of human papillomaviruses. Urology1994; 44: 671. Google Scholar 23 : Human papillomavirus infection of the uterine cervix of women without cytological signs of neoplasia. Brit. Med. J.1986; 293: 1261. Google Scholar 24 : Detection of human papillomavirus types 16 and 18 in primary and in metastatic lesions of cervical carcinomas. Gynec. Oncol.1994; 53: 156. Google Scholar Departments of Obstetrics and Gynecology, and Urology, Saga Medical School, Saga, Japan.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byGutiérrez J, Jiménez A, de Dios Luna J, Soto M and Sorlózano A (2018) Meta-Analysis of Studies Analyzing the Relationship Between Bladder Cancer and Infection by Human PapillomavirusJournal of Urology, VOL. 176, NO. 6, (2474-2481), Online publication date: 1-Dec-2006.Aynaud O, Tranbaloc P and Orth G (2018) LACK OF EVIDENCE FOR A ROLE OF HUMAN PAPILLOMAVIRUSES IN TRANSITIONAL CELL CARCINOMA OF THE BLADDERJournal of Urology, VOL. 159, NO. 1, (86-90), Online publication date: 1-Jan-1998. Volume 155Issue 2February 1996Page: 471-474 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Mansuka Mvula More articles by this author Tsuyoshi Iwasaka More articles by this author Atsushi Iguchi More articles by this author Satoru Nakamura More articles by this author Zenjiro Masaki More articles by this author Hajime Sugimori More articles by this author Expand All Advertisement PDF downloadLoading ...