UNC Libraries · 2020 · 140 citations · 0 references
MedicineNeurologyNeuroscienceClinical NeuroscienceNeuropsychiatryNeuropsychologyAntiretroviral TherapyHiv DiagnosisNeurocognitive DisordersNeurodevelopmental DisordersNeuropathology Of InfectionNeuropsychiatric DisordersHiv SusceptibilityHiv-associated Cognitive ImpairmentHiv-associated DementiaHiv-associated NeuropathologyNeurologic Toxicity Of Antiretrovirals
In 1991, the American Academy of Neurology published nomenclature and case definitions to guide diagnosis of HIV‑1 neurologic manifestations. The working group was tasked to critically review and update HIV‑associated neurocognitive disorder definitions and propose an algorithm for standardized diagnosis. The report reviews HAND experience post‑HAART, examines comorbidities, proposes adding asymptomatic neurocognitive impairment, and presents an algorithm for standardized classification. The report reflects a majority consensus, though not all points were unanimous.
In 1991, the AIDS Task Force of the American Academy of Neurology published nomenclature and research case definitions to guide the diagnosis of neurologic manifestations of HIV-1 infection. Now, 16 years later, the National Institute of Mental Health and the National Institute of Neurological Diseases and Stroke have charged a working group to critically review the adequacy and utility of these definitional criteria and to identify aspects that require updating. This report represents a majority view, and unanimity was not reached on all points. It reviews our collective experience with HIV-associated neurocognitive disorders (HAND), particularly since the advent of highly active antiretroviral treatment, and their definitional criteria; discusses the impact of comorbidities; and suggests inclusion of the term asymptomatic neurocognitive impairment to categorize individuals with subclinical impairment. An algorithm is proposed to assist in standardized diagnostic classification of HAND.