Concepedia

Orientin downregulating oxidative stress-mediated endoplasmic reticulum stress and mitochondrial dysfunction through AMPK/SIRT1 pathway in rat nucleus pulposus cells in vitro and attenuated intervertebral disc degeneration in vivo

Zhao Zhang, Jingtao Wu, Cheng Teng, Jinquan Wang, Jiapei Yu, Chen Jin, Libo Wang, Long Wu, Zhen Lin, Ziping Yu,

APOPTOSIS · 2022 · 47 citations · 32 references

DOI

Concepts

References

32

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Kenneth J. Livak, Thomas D. Schmittgen · Methods · 2001 · 176.9K citations

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

PubMed · 1997 · 66.5K citations

A Simple Disc Degeneration Model Induced by Percutaneous Needle Puncture in the Rat Tail

Bin Han, Kai Zhu, Fangcai Li et al. · Spine · 2008 · 418 citations

Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo

Zhiwei Liao, Rongjin Luo, Gaocai Li et al. · Theranostics · 2019 · 410 citations · Full text

A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation

Jin Rui Liang, Emily Lingeman, Thao Luong et al. · Cell · 2020 · 301 citations · Full text