Total synthesis of structurally diverse pleuromutilin antibiotics

Predictive compound accumulation rules yield a broad-spectrum antibiotic

Michelle F. Richter, Bryon Drown, Andrew P. Riley et al. · Nature · 2017 · 886 citations

Pharmacy, Medicinal Chemistry, Drug Discovery +4

Synthesis of .alpha.,.beta.-unsaturated carbonyl compounds by palladium(II)-catalyzed dehydrosilylation of silyl enol ethers

Yoshihiko Ito, Toshikazu Hirao, Takeo Saegusa · The Journal of Organic Chemistry · 1978 · 861 citations

Natural Sciences, Chemistry, Catalysis +5

A platform for the discovery of new macrolide antibiotics

Ian B. Seiple, Ziyang Zhang, Pavol Jakubec et al. · Nature · 2016 · 352 citations · Full text

Pharmacy, Medicinal Chemistry, Microbiology +12

Directing effects in homogeneous hydrogenation with [Ir(cod)(PCy3)(py)]PF6

Robert H. Crabtree, Mark W. Davis · The Journal of Organic Chemistry · 1986 · 340 citations

Natural Sciences, Chemistry, Materials Science +8

A mild oxidizing reagent for alcohols and 1,2-diols: o-Iodoxybenzoic acid (IBX) in DMSO

M. FRIGERIO · Tetrahedron Letters · 1994 · 238 citations

Natural Sciences, Chemistry, Organic Chemistry +4