European Journal of Immunology · 2001 · 111 citations · 33 references
Veterinary MedicineImmunologyInfectious DiseasesImmunizationVaccine ImmunologyVaccinologyAdaptive Immune ResponsesCellular Immune ResponsesImmune Response To VaccinationMalariaParasite AntigensT-cell Responses To ParasitesCd4 Positive T Cell ResponsesCd8 Positive T Cell ResponsesCellular Immune Response To ParasitesMalaria ImmunologyMalaria VaccinesPlasmodium FalciparumSynthetic VaccineVaccination Strategies
We report the first synthetic peptide vaccine eliciting strong CD8+ and CD4+ T lymphocyte responses in humans. The vaccine, representing the C-terminal region of the circumsporozoite protein of Plasmodium falciparum (amino acids 282–383) was well tolerated and strong sporozoite-specific antibodies were elicited. In addition, robust lymphocyte proliferation responses were equally elicited with concomitant in vitro production of IFN-γ, crucial in the elimination of the parasite. Most importantly, we also observed the development of CD8+ T lymphocyte responses decisive in the immunity to malaria. The latter finding opens new, possibly safer, avenues for vaccination strategies when a CD8+ T cell response is needed.
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Induction of Antigen-Specific Cytotoxic T Lymphocytes in Humans by a Malaria DNA Vaccine
Ruobing Wang, Denise L. Doolan, Thong P. Le et al. · Science · 1998 · 841 citations
Jörg Schneider, Sarah C. Gilbert, Tom Blanchard et al. · Nature Medicine · 1998 · 649 citations