Concepedia

Controllable methylenation with ethylene glycol as the methylene source: bridging enaminones and synthesis of tetrahydropyrimidines

Yulei Zhao, Huimin Wang, Xin Kang, Ruihua Zhang, Nan Feng, Qi Su

Organic Chemistry Frontiers · 2022 · 18 citations · 50 references

DOI

Concepts

Abstract

Controllable methylenation using renewable ethylene glycol as the methylene source has been developed for the introduction of one or two methylene building blocks.

References

50

Using carbon dioxide as a building block in organic synthesis

Qiang Liu, Lipeng Wu, Ralf Jackstell et al. · Nature Communications · 2015 · 2.1K citations · Full text

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Palladium‐Catalyzed Oxidative Cyclization of <i>N</i>‐Aryl Enamines: From Anilines to Indoles

Sebastian Würtz, Souvik Rakshit, Julia J. Neumann et al. · Angewandte Chemie International Edition · 2008 · 456 citations

, , +12

Radical Carboxylative Cyclizations and Carboxylations with CO<sub>2</sub>

Jian‐Heng Ye, Tao Ju, He Huang et al. · Accounts of Chemical Research · 2021 · 420 citations

, , +6

Ligand-accelerated enantioselective methylene C(sp <sup>3</sup> )–H bond activation

Gang Chen, Wei Gong, Zhe Zhuang et al. · Science · 2016 · 347 citations · Full text

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The Applications of Dimethyl Sulfoxide as Reagent in Organic Synthesis

Xiao‐Feng Wu, Kishore Natte · Advanced Synthesis & Catalysis · 2016 · 347 citations

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