Multidomain peptide hydrogel adjuvants elicit strong bias towards humoral immunity

Brett H. Pogostin, Marina H. Yu, Alon R. Azares, Erin M. Euliano, Cheuk Sun Edwin Lai, Gabriel Saenz, Samuel X. Wu, Adam C. Farsheed, Sarah M. Melhorn, Tyler P. Graf,

Biomaterials Science · 2022 · 22 citations · 41 references

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Abstract

T splenocytes compared to mice vaccinated alum-adjuvanted OVA. Together, the data suggest that MDP hydrogel adjuvants strongly bias the immune response towards humoral immunity while evoking a very limited cellular immune response. As a result, MDPs may have the potential to serve as adjuvants for applications that benefit exclusively from humoral immunity.

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