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Synthesis and pharmacological characterization of multiply substituted 2H-chromene derivatives as P2Y6 receptor antagonists

Kwan‐Young Jung, Qasim Shah, Sarah A. Lewicki, Asmita Pramanik, Varun Gopinatth, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, Kenneth A. Jacobson

Bioorganic & Medicinal Chemistry Letters · 2022 · 17 citations · 25 references

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25

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Tim R. Mosmann · Journal of Immunological Methods · 1983 · 55.6K citations

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Automated design of ligands to polypharmacological profiles

Jérémy Besnard, G.F. Ruda, Vincent Setola et al. · Nature · 2012 · 845 citations · Full text

, , +14

UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis

Schuichi Koizumi, Yukari Shigemoto‐Mogami, Kaoru Nasu‐Tada et al. · Nature · 2007 · 808 citations

, , +14

Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors

Liaman K. Mamedova, Bhalchandra V. Joshi, Zhan‐Guo Gao et al. · Biochemical Pharmacology · 2004 · 166 citations

, , +8

Slow desensitization of the human P2Y6 receptor

Bernard Robaye, J.M. Boeynaems, Didier Communi · European Journal of Pharmacology · 1997 · 99 citations

, , +14