Concepedia

Publication | Open Access

VRK1 Is a Synthetic–Lethal Target in VRK2-Deficient Glioblastoma

DOIFull Paper Access

64

Citations

51

References

2022

Year

Julie A. Shields, Samuel R. Meier, Madhavi Bandi, Erin E. Mulkearns-Hubert, Nicole Hajdari, Maria Dam Ferdinez, Justin L. Engel, Daniel J. Silver, Binzhang Shen, Wenhai Zhang,
Cancer Research

Abstract

A paralog synthetic-lethal interaction between VRK1 and VRK2 sensitizes VRK2-methylated glioblastoma to perturbation of VRK1 kinase activity, supporting VRK1 as a drug discovery target in this disease.

References

YearCitations

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