Chemoimmunotherapy for Meningeal Melanocytoma of the Thoracic Spinal Cord

Abstract

THE MEDIAN survival of patients with primary melanomas of the CNS is approximately five months. A pigmented primary lesion of leptomeninges, usually causing symptoms from local expansion, has also been described and variously called pigmented meningioma, melanotic meningioma, and meningeal melanocytoma.^1-5Thorough excision may result in cure or at least ensure a prolonged survival.³ The occasional spontaneous disappearance or regression of the primary lesion in malignant melanoma and studies suggesting involvement of the immune system in host defenses have led to various immunotherapeutic approaches in the control of this and other kinds of neoplasms. We know of no previous description in the literature of treatment of meningeal melanocytoma other than surgical removal of the local tumor. This case of meningeal melanocytoma emphasizes its rare occurrence and recurring clinical course if not excised completely. <h3>Report of a Case</h3> A 71-year-old woman was admitted to the neurosurgery service in August