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Discovery of 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one and 3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one derivatives as novel ENPP1 inhibitors

Jae Eun Jung, Yunseong Jang, Hee Jin Jeong, Sung Joon Kim, Ki Chul Park, Do Hee Oh, Ah-Ran Yu, Chan Sun Park, Seo‐Jung Han

Bioorganic & Medicinal Chemistry Letters · 2022 · 12 citations · 16 references

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

Hiroki Ishikawa, Zhe Ma, Glen N. Barber · Nature · 2009 · 2.7K citations · Full text

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A decade of immune-checkpoint inhibitors in cancer therapy

Caroline Robert · Nature Communications · 2020 · 1.6K citations · Full text

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Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

Lingyin Li, Qian Yin, Pia Kuss et al. · Nature Chemical Biology · 2014 · 522 citations · Full text

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Extracellular cGAMP is a cancer-cell-produced immunotransmitter involved in radiation-induced anticancer immunity

Jacqueline A. Carozza, Volker Böhnert, Khanh Cong Nguyen et al. · Nature Cancer · 2020 · 334 citations · Full text

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Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1

Kazuki Kato, Hiroshi Nishimasu, Daisuke Oikawa et al. · Nature Communications · 2018 · 173 citations · Full text

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