Gut Epithelial Inositol Polyphosphate Multikinase Alleviates Experimental Colitis via Governing Tuft Cell Homeostasis

Abstract

Depletion of inositol polyphosphate multikinase in mouse intestinal epithelium aggravates experimental colitis. Cholinergic tuft cells but no other intestinal cells are decreased by Ipmk deletion, revealing the role of inositol polyphosphate multikinase in maintaining gut integrity via determining tuft cell homeostasis.