Concepedia

Primary Biliary Cirrhosis

Marshall M. Kaplan, M. Eric Gershwin

New England Journal of Medicine · 2005 · 1.2K citations · 75 references

DOI

Concepts

Abstract

Primary biliary cirrhosis, a slowly progressive autoimmune liver disease characterized by portal inflammation and an immune-mediated destruction of the intrahepatic bile ducts, leads to decreased bile secretion and the retention of toxic substances within the liver. This review considers new data concerning both the autoimmune responses involved and the treatment of primary biliary cirrhosis.

References

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Primary biliary cirrhosis in monozygotic and dizygotic twins: Genetics, epigenetics, and environment

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Primary Biliary Cirrhosis

Marshall M. Kaplan · New England Journal of Medicine · 1996 · 457 citations

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