Concepedia

Electrophilic Reagents for the Direct Incorporation of Uncommon SCF <sub>2</sub> CF <sub>2</sub> H and SCF <sub>2</sub> CF <sub>3</sub> Motifs

Jordi Mestre, Miguel Bernús, Sergio Castillón, Omar Boutureira

The Journal of Organic Chemistry · 2022 · 19 citations · 64 references

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Concepts

Abstract

motifs. Their reactivity performance, multigram-scale preparation, and divergent derivatization have been thoroughly investigated with a variety of nucleophiles, including natural products and pharmaceuticals.

References

64

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Metabolic and Pharmaceutical Aspects of Fluorinated Compounds

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Fast Calculation of van der Waals Volume as a Sum of Atomic and Bond Contributions and Its Application to Drug Compounds

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Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept

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, , +14