Imperatorin Inhibits Proliferation, Migration, and Inflammation <i>via</i> Blocking the NF-κB and MAPK Pathways in Rheumatoid Fibroblast-like Synoviocytes

Abstract

the mitogen-activated protein kinase (MAPK) (p38 and ERK) and NF-κB pathways leading to the down-regulation of pro-inflammatory cytokines, which might be beneficial to the anti-proliferative and anti-migratory activities of FLS cells. These findings suggest that IPT has the potential to be developed as a novel agent for RA treatment.