Diabetes is accompanied by changes in the levels of proteins involved in endosomal <scp>GLUT4</scp> trafficking in obese human skeletal muscle

Abstract

We report significant reductions of proteins involved in the endosomal trafficking of GLUT4 in skeletal muscle in obese people with type 2 diabetes compared with age- and weight-matched controls. These abnormalities of intracellular GLUT4 trafficking may contribute to reduced whole body insulin sensitivity.