Copper-Catalyzed Cross-Coupling of Alkyl and Phosphorus Radicals for C(sp³)–P Bond Formation

Abstract

A Cu^I-catalyzed cross-coupling of alkyl- and phosphorus-centered radicals for C(sp³)-P bond formation is introduced. Diacyl peroxides, generated in situ from aliphatic acids and H₂O₂, serve as a source for alkyl radicals and also an initiator for the generation of phosphorus radicals from H-P(O) compounds.