Concepedia

CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer

Chia‐Lun Hong, I‐Shing Yu, Chen‐Hsueh Pai, Jin‐Shing Chen, Min‐Shu Hsieh, Hua‐Lin Wu, Shu‐Wha Lin, Hsiang–Po Huang

Cancer Research · 2022 · 55 citations · 38 references

DOIFull text

Open access

Abstract

These findings demonstrate that CD248 maintains pericyte function in lung cancer through the Wnt signaling pathway and present CD248 as a potential therapeutic target.

References

38

Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer

Alan Sandler, Robert J. Gray, Michael C. Perry et al. · New England Journal of Medicine · 2006 · 5.8K citations · Full text

Genes Expressed in Human Tumor Endothelium

Brad St. Croix, Carlo Rago, Victor E. Velculescu et al. · Science · 2000 · 1.8K citations

, , +16

Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling

Bingyu Mao, Wei Wu, Gary Davidson et al. · Nature · 2002 · 1K citations

, , +6

Overall survival with cisplatin–gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL)

Martin Reck, Joachim von Pawel, Petr Zatloukal et al. · Annals of Oncology · 2010 · 640 citations · Full text

, , +8

Ramucirumab plus erlotinib in patients with untreated, EGFR-mutated, advanced non-small-cell lung cancer (RELAY): a randomised, double-blind, placebo-controlled, phase 3 trial

Kazuhiko Nakagawa, Edward B. Garon, Takashi Seto et al. · The Lancet Oncology · 2019 · 594 citations · Full text

, , +5