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Accuracy of high-risk HPV DNA PCR, p16(INK4a) immunohistochemistry or the combination of both to diagnose HPV-driven oropharyngeal cancer

Cindy Simoens, Tarik Gheit, Ruediger Ridder, Ivana Gorbašlieva, Dana Holzinger, Eric Lucas, Susanne Rehm, Peter Vermeulen, Martin Lammens, Olivier M. Vanderveken,

BMC Infectious Diseases · 2022 · 22 citations · 35 references

DOIFull text

Open access

Abstract

Single hrHPV DNA PCR and p16<sup>(INK4a)</sup> IHC are highly sensitive but less specific than using combined testing to diagnose HPV-driven OPC patients. Disease prognostication can be encouraged based on this combined test result.

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