<i>Dermatophagoides pteronyssinus</i> allergen Der p 22: Cloning, expression, <scp>IgE</scp> ‐binding in asthmatic children, and immunogenicity

Abstract

Recombinant Der p 22 exhibited high IgE-binding rates in allergic children, indicating the activity of the recombinant protein and suggesting this novel allergen may be appropriate for inclusion in an allergy diagnostic workup. This finding is supported by in vitro and mouse in vivo studies showing rDer p 22 induced strong allergenic reactivity and apoptosis.