In vitro Evaluation (Antioxidant Activity) of coumarin derivatives

Abstract

Coumarin is a heterocyclic molecule associated with beneficial human health effects such as to reduce the risk of cancer, diabetes, cardiovascular and brain disease. These effects are thought to be related to free radical scavenging due to their antioxidant properties. Coumarin is a substance that has been synthesized in many of its derivatives in recent years. This entity is a major source of interest for many medicinal chemists to explore its various pharmacological possibilities, especially anticoagulant activity. The antioxidant activities of two synthesized coumarin derivatives namely 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N'-(1-(4-aminophenyl)ethylidene) acetohydra zide [M1] and 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N'-(1-(2 hydroxy phenyl) ethylidene) acetohydrazide [M2] were studied with the DPPH method. Structure of two coumarin synthesized compounds is proposed on the basis of spectroscopic evidence.