Concepedia

Regulation of PPAR-γ activity in lipid-laden hepatocytes affects macrophage polarization and inflammation in nonalcoholic fatty liver disease

Xiaoyun Li, Pei‐Xuan Ji, Xi‐Xi Ni, Yuxin Chen, Sheng Li, Min Lian, Can‐Jie Guo, Jing Hua

World Journal of Hepatology · 2022 · 16 citations · 21 references

DOIFull text

Open access

Abstract

Upregulation of PPAR-γ activity in hepatocytes alleviated NAFLD by modulating the crosstalk between hepatocytes and macrophages <i>via</i> the reactive oxygen species-NLRP3-IL-1β pathway.

References

21

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

Mercedes Ricote, Andrew C. Li, Timothy M. Willson et al. · Nature · 1998 · 3.5K citations

, , +11

A human hepatocellular in vitro model to investigate steatosis

María José Gómez‐Lechón, M. Teresa Donato, Alicia Martínez‐Romero et al. · Chemico-Biological Interactions · 2006 · 557 citations

, , +6

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

Wan Huang, Anantha S. Metlakunta, Nikolaos Dedousis et al. · Diabetes · 2009 · 500 citations · Full text

Kupffer Cells Promote Hepatic Steatosis Via Interleukin-1β–Dependent Suppression of Peroxisome Proliferator-Activated Receptor α Activity

Rinke Stienstra, Fredy Z. Saudale, Caroline Duval et al. · Hepatology · 2009 · 441 citations

Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production

Annie‐Carole Tosello‐Trampont, Susan G. Landes, Virginia Nguyen et al. · Journal of Biological Chemistry · 2012 · 406 citations · Full text