Life SciencesImmunologyPharmacologyCell SignalingInflammationInnate ImmunityGastrointestinal InflammationInflammasome ActivationInflammatory Bowel DiseaseInflammatory Cell SignalingInflammatory SignalingMucosal InflammationGasdermin D-mediated PyroptosisInflammatory Bowel Disease PathogenesisInflammatory Bowel Disease PathophysiologyPro-inflammatory Signaling PathwaysPyroptosis Mechanisms
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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Jianjin Shi, Yue Zhao, Kun Wang et al. · Nature · 2015 · 6.5K citations
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
Xing Liu, Zhibin Zhang, Jianbin Ruan et al. · Nature · 2016 · 3.2K citations · Full text
Non-canonical inflammasome activation targets caspase-11
Nobuhiko Kayagaki, Søren Warming, Mohamed Lamkanfi et al. · Nature · 2011 · 2.5K citations
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
Wanting He, Haoqiang Wan, Lichen Hu et al. · Cell Research · 2015 · 2.5K citations · Full text
Inflammatory caspases are innate immune receptors for intracellular LPS
Jianjin Shi, Yue Zhao, Yupeng Wang et al. · Nature · 2014 · 2.2K citations