Concepedia

Metabolic rescue ameliorates mitochondrial encephalo‐cardiomyopathy in murine and human iPSC models of Leigh syndrome

Jin‐Young Yoon, Nastaran Daneshgar, Yi Chu, Biyi Chen, Marco M. Hefti, Ajit Vikram, Kaikobad Irani, Long‐Sheng Song, Charles Brenner, E. Dale Abel,

Clinical and Translational Medicine · 2022 · 32 citations · 46 references

DOIFull text

Open access

Abstract

Our study reveals direct mechanistic explanations of the observed cardiac bradyarrhythmia, diastolic dysfunction and neuronal apoptosis in mouse and human induced pluripotent stem cells (iPSC) models of LS.

References

46

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

Wei Gu, R G Roeder · Cell · 1997 · 2.5K citations · Full text

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Multiple Inference and Gender Differences in the Effects of Early Intervention: A Reevaluation of the Abecedarian, Perry Preschool, and Early Training Projects

Michael Anderson · Journal of the American Statistical Association · 2008 · 2.3K citations

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

Jianyuan Luo, Anatoly Nikolaev, Shin‐ichiro Imai et al. · Cell · 2001 · 2.1K citations · Full text

, , +9

Distinct Metabolic Flow Enables Large-Scale Purification of Mouse and Human Pluripotent Stem Cell-Derived Cardiomyocytes

Shugo Tohyama, Fumiyuki Hattori, Motoaki Sano et al. · Cell stem cell · 2012 · 1.1K citations · Full text

, , +7

Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells

Marco Spinazzi, Alberto Casarin, Vanessa Pertegato et al. · Nature Protocols · 2012 · 982 citations

, , +7