The Apelin-APJ axis alleviates LPS-induced pulmonary fibrosis and endothelial mesenchymal transformation in mice by promoting Angiotensin-Converting Enzyme 2

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury

Keiji Kuba, Yumiko Imai, Shuan Rao et al. · Nature Medicine · 2005 · 3.6K citations · Full text

Veterinary Medicine, Infectious Diseases, Pathobiology +14

Angiotensin-converting enzyme 2 protects from severe acute lung failure

Yumiko Imai, Keiji Kuba, Shuan Rao et al. · Nature · 2005 · 2.6K citations · Full text

Medicine, Pathobiology, Inflammation +10

Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor

Kazuhiko Tatemoto, Masaki Hosoya, Yugo Habata et al. · Biochemical and Biophysical Research Communications · 1998 · 1.7K citations

Medicine, Medicinal Chemistry, Pharmacology +10

Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS‐CoV) in SARS patients: implications for pathogenesis and virus transmission pathways

Yanqing Ding, Li He, Qingling Zhang et al. · The Journal of Pathology · 2004 · 1.1K citations · Full text

Veterinary Medicine, Infectious Diseases, Molecular Biology +15

A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11

Brian F. O’Dowd, Michael Heiber, Audrey Chan et al. · Gene · 1993 · 840 citations

Life Sciences, Genetics, Molecular Genetics +5