Development of a nanoparticle-based immunotherapy targeting PD-L1 and PLK1 for lung cancer treatment

Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer

Martin Reck, Delvys Rodríguez‐Abreu, Andrew Robinson et al. · New England Journal of Medicine · 2016 · 9.8K citations · Full text

Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

Naiyer A. Rizvi, Matthew D. Hellmann, Alexandra Snyder et al. · Science · 2015 · 7.8K citations · Full text

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

Joshua D. Campbell, Anton Alexandrov, Jaegil Kim et al. · Nature Genetics · 2016 · 1.2K citations · Full text

Somatic Variant, Distinct Patterns, Genetics +8

Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

Jinfang Zhang, Xia Bu, Haizhen Wang et al. · Nature · 2017 · 1K citations · Full text

Tumor Biology, Cancer Immune Surveillance, Cancer Immunosurveillance +12

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

Limo Chen, Don L. Gibbons, Sangeeta Goswami et al. · Nature Communications · 2014 · 970 citations · Full text

Intratumoral Immunosuppression, Microrna-200/zeb1 Axis Control, Medicine +9