BRD4 inhibition by JQ1 protects against LPS-induced cardiac dysfunction by inhibiting activation of NLRP3 inflammasomes

Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway

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BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice

Erica Korb, Margo Herre, Ilana Zucker-Scharff et al. · Nature Neuroscience · 2015 · 238 citations · Full text

Knockout Mouse, Transcriptional Regulation, Molecular Neuroscience +11

Left ventricular systolic dysfunction during septic shock: the role of loading conditions

Florence Boissier, Keyvan Razazi, Aurélien Seemann et al. · Intensive Care Medicine · 2017 · 194 citations

Heart Failure, Cardiogenic Shock, Sepsis +6

RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation

Homa Rahnamoun, Ji Hoon Lee, Zhengxi Sun et al. · Nature Structural & Molecular Biology · 2018 · 184 citations

Chromatin, Transcriptional Regulation, Enhanced Chromatin Engagement +12

Inhibition of BRD4 prevents proliferation and epithelial–mesenchymal transition in renal cell carcinoma via NLRP3 inflammasome-induced pyroptosis

Yi-Fan Tan, Min Wang, Zhiyuan Chen et al. · Cell Death and Disease · 2020 · 133 citations · Full text