Microbiology Spectrum · 2022 · 22 citations · 46 references
Life SciencesMicrobiologyMolecular BiologyEnzymologyNucleic Acid BiochemistryRna ProcessingOxidative Stress In CarcinogenesisRibonucleic Acid (Rna) ChemistryRna ModificationRna TranscriptionRna-binding ProteinsRna-protein InteractionsDead-box Rna HelicasesExtremophilic BacteriaMessenger Rna Binding ProteinsOxidative Stress AdaptationRibonucleotide ChemistryRna Helicase ActivityRrna ModificationTermination Factor Function
Oxidative RNA damage can be caused by oxidative stress, such as hydrogen peroxide, ionizing radiation, and antibiotic treatment. 8-oxo-7,8-dihydroguanine (8-oxoG), a major type of oxidized RNA, is highly mutagenic and participates in a variety of disease occurrences and development. Although several proteins have been identified to recognize 8-oxoG-modified RNA, the knowledge of how RNA oxidative damage is controlled largely remains unclear, especially in nonmodel organisms.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
PubMed · 1997 · 66.6K citations
The Biology of Oxygen Radicals
Irwin Fridovich · Science · 1978 · 3.3K citations