Highly Sensitive <i>EGFRvIII</i> Detection in Circulating Extracellular Vesicle RNA of Glioma Patients

Abstract

This study demonstrates the feasibility of detecting EGFRvIII mutation in plasma using a highly sensitive and specific ddPCR assay. We also show a higher than previously reported EGFRvIII prevalence in glioma tumor tissue. Several features of the assay are favorable for clinical implementation for detection and monitoring of EGFRvIII-positive tumors.