Metformin use is not associated with colorectal cancer incidence in type-2 diabetes patients: evidence from methods that avoid immortal time bias

Real-World Evidence — What Is It and What Can It Tell Us?

Rachel E. Sherman, Steven A. Anderson, Gerald J. Dal Pan et al. · New England Journal of Medicine · 2016 · 2.1K citations

Law, Health Informatics, Health Policy +17

Total Cholesterol and Cancer Risk in a Large Prospective Study in Korea

Cari M. Kitahara, Amy Berrington de González, Neal D. Freedman et al. · Journal of Clinical Oncology · 2011 · 414 citations · Full text

Medicine, Oncology, Cancer Epidemiology +8

Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial

Takuma Higurashi, Kunihiro Hosono, Hirokazu Takahashi et al. · The Lancet Oncology · 2016 · 340 citations

Medicine, Oncology, Pharmacology +9

Metformin Does Not Affect Cancer Risk: A Cohort Study in the U.K. Clinical Practice Research Datalink Analyzed Like an Intention-to-Treat Trial

Konstantinos K. Tsilidis, Despoina Capothanassi, Naomi E. Allen et al. · Diabetes Care · 2014 · 183 citations

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Immortal time bias in observational studies of time-to-event outcomes

Mark Jones, Robert Fowler · Journal of Critical Care · 2016 · 180 citations

Medicine, Biostatistics, Oncology +16