Concepedia

Diabetes impairs cardioprotective function of endothelial progenitor cell-derived extracellular vesicles via H3K9Ac inhibition

Grace Huang, Zhongjian Cheng, Alycia N. Hildebrand, Chunlin Wang, Maria Cimini, Rajika Roy, Anna Maria Lucchese, Cindy Benedict, Vandana Mallaredy, Ajit Magadum,

Theranostics · 2022 · 41 citations · 28 references

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Concepts

Abstract

Our findings unravel that diabetes impairs EPC-EV reparative function in the ischemic heart, at least partially, through HDACs-mediated H3K9Ac downregulation leading to transcriptional suppression of angiogenic, proliferative and cell survival genes in recipient cardiac ECs. Thus, HDAC inhibitors may potentially be used to restore the function of diabetic EPC and other stem cells for autologous cell therapy applications.

References

28

Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

Min Xiu, Juanjuan Xing, Shaoqing Yu et al. · Cellular Physiology and Biochemistry · 2017 · 5.8K citations · Full text

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A Protocol for Exosome Isolation and Characterization: Evaluation of Ultracentrifugation, Density-Gradient Separation, and Immunoaffinity Capture Methods

David W. Greening, Rong Xu, Hong Ji et al. · Methods in molecular biology · 2015 · 715 citations

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Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

Daniella Brasacchio, Jun Okabe, Christos Tikellis et al. · Diabetes · 2009 · 531 citations · Full text

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Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes

Louisa M. Villeneuve, Marpadga A. Reddy, Linda Lanting et al. · Proceedings of the National Academy of Sciences · 2008 · 411 citations · Full text

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ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart

Jung-Kang Jin, Erik A. Blackwood, Khalid Azizi et al. · Circulation Research · 2016 · 329 citations · Full text

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