Natural polymer Effect on gelation and rheology of ketotifen-loaded pH-sensitive in situ ocular gel (Carbapol)

Abstract

In situ gel can be defined as a polymer solution administered as a liquid and when exposed to some physiologic condition such as the pH, ionic, temperature modulation or solvent and UV induced gelation undergo to phase transition to a semisolid gel. Ketotifen fumarate belongs to the histamine H1 receptor antagonists, and Ketotifen fumarate is used in the treatment of allergic conditions like conjunctivitis and rhinitis. This work aims to study the natural polymer effects (xanthan gum,gellan gum)