Concepedia

Neutrophil extracellular traps mediate m<sup>6</sup>A modification and regulates sepsis-associated acute lung injury by activating ferroptosis in alveolar epithelial cells

Hao Zhang, Jinlong Liu, Yilu Zhou, Mengdi Qu, Yanghanzhao Wang, Kefang Guo, Ruling Shen, Zhirong Sun, Juan P. Cata, Shuofei Yang,

International Journal of Biological Sciences · 2022 · 328 citations · 49 references

DOIFull text

Open access

Concepts

Abstract

, we elucidated and confirmed the critical role of ferroptosis in NETs-induced ALI. These findings support a role for NETs-induced METTL3 modification and the subsequent induction of ferroptosis in the pathogenesis of sepsis-associated ALI.

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