Prenatal diagnosis and pregnancy outcome of major structural anomalies detectable in the first trimester: A population‐based cohort study in the Netherlands

Abstract

Major structural anomalies amenable to early diagnosis in the first trimester of pregnancy are mostly diagnosed during the second trimester in the absence of a regulated first-trimester anatomical screening programme in the Netherlands and are associated with TOPFA and spontaneous death, especially in cases with underlying genetic anomalies.