The Journal of Organic Chemistry · 2022 · 42 citations · 48 references
Valuable Phosphine-containing QuinazolinonesBroad Substrate ScopeEngineeringPhosphine-containing QuinazolinonesPhotochemistryBiochemistryNatural SciencesHeterocyclicMechanistic PhotochemistryPhotoredox ProcessMolecular SwitchSynthetic PhotochemistryOrganic ChemistryPhoto-induced Radical Phosphorylation/cyclizationChemistryHeterocycle ChemistryUnactivated AlkenesBiomolecular Engineering
A mild and facile photo-induced cascade radical addition/cyclization of unactivated alkenes has been reported, through which a variety of biologically valuable phosphine-containing quinazolinones could be obtained in moderate to good yields. The protocol was characterized by mild conditions, broad substrate scope, and high atomic economy.
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