Concepedia

Oridonin represses epithelial-mesenchymal transition and angiogenesis of thyroid cancer via downregulating JAK2/STAT3 signaling

Wei Liu, Xindi Wang, Le Wang, Yu Mei, Yanning Yun, Xiaobao Yao, Qian Chen, Jinsong Zhou, Bo Kou

International Journal of Medical Sciences · 2022 · 58 citations · 29 references

DOIFull text

Open access

Concepts

Abstract

results further confirmed that oridonin inhibited tumorigenicity in thyroid cancer xenograft. In conclusion, the results demonstrated that oridonin repressed metastatic phenotype, angiogenesis and modulated EMT (epithelial-mesenchymal transition) of thyroid cancer cells via the inactivation of JAK2/STAT3 signaling pathway, suggesting that JAK2 may be a novel therapeutic target of oridonin against thyroid cancer.

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