Concepedia

Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis

Nikola Kenjić, Kathleen M. Meneely, Daniel Wherritt, Melissa C. Denler, Timothy A. Jackson, Graham R. Moran, Audrey L. Lamb

Journal of the American Chemical Society · 2022 · 13 citations · 54 references

DOI Full text

Open access

Concepts

Life SciencesBiochemistryChemistryEnzymologyStructural BiologyRibonucleic Acid (Rna) ChemistryRiboflavin BiosynthesisRibonucleotide Chemistry

Abstract

soaks of VcRibB-d-Ru5P crystals show accumulation in crystallo of the same intermediates. Collectively, these data reveal for the first time crucial transient chemical states in the mechanism of RibB.

References

54

Features and development of Coot

Paul Emsley, Bernhard Lohkamp, W. G. Scott et al. · Acta Crystallographica Section D Biological Crystallography · 2010 · 29.6K citations · Full text

Natural Sciences, Chemistry, Biomolecular Modeling +16

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Paul D. Adams, Pavel V. Afonine, G. Bunkóczi et al. · Acta Crystallographica Section D Biological Crystallography · 2010 · 24.5K citations · Full text

Natural Sciences, Biophysics, Computational Biology +16

Phasercrystallographic software

Airlie J. McCoy, Ralf W. Grosse‐Kunstleve, Paul D. Adams et al. · Journal of Applied Crystallography · 2007 · 20.9K citations · Full text

Natural Sciences, Chemistry, Computational Chemistry +16

Towards automated crystallographic structure refinement with phenix.refine

Pavel V. Afonine, Ralf W. Grosse‐Kunstleve, Nathaniel Echols et al. · Acta Crystallographica Section D Biological Crystallography · 2012 · 5.7K citations · Full text

Natural Sciences, Chemistry, Computational Chemistry +15

Genes required for mycobacterial growth defined by high density mutagenesis

Christopher M. Sassetti, Dana Boyd, Eric J. Rubin · Molecular Microbiology · 2003 · 2.6K citations · Full text

Life Sciences, Genetics, Microbiology +12