Concepedia

Hydroxy-directed fluorination of remote unactivated C(sp<sup>3</sup>)–H bonds: a new age of diastereoselective radical fluorination

Stefan Andrew Harry, Michael Richard Xiang, Eric Holt, Andrea Zhu, Fereshte Ghorbani, Dhaval Patel, Thomas Lectka

Chemical Science · 2022 · 35 citations · 83 references

DOIFull text

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Concepts

Abstract

We report a photochemical, hydroxy-directed fluorination that addresses the prevailing challenge of high diastereoselectivity. Numerous motifs showcase a range of regio- and stereochemical outcomes based on the configuration of the hydroxy group.

References

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