Concepedia

Caspase-3–Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma

Etienne Ho Kit Mok, Carmen Leung, Lei Zhou, Martina Mang Leng Lei, Hoi-Wing Leung, Man Tong, Tin Lok Wong, Eunice Y. Lau, Irene Oi‐Lin Ng, Jin Ding,

Cancer Research · 2022 · 92 citations · 41 references

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Abstract

This study finds that cholesterol biosynthesis supports the expansion of cancer stem cell populations to drive resistance to tyrosine kinase inhibitor therapy in hepatocellular carcinoma, identifying potential therapeutic approaches for improving cancer treatment.

References

41

Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

Ann‐Lii Cheng, Yoon‐Koo Kang, Zhendong Chen et al. · The Lancet Oncology · 2008 · 5.8K citations

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Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial

Masatoshi Kudo, Richard S. Finn, Shukui Qin et al. · The Lancet · 2018 · 5.3K citations · Full text

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Identification and Characterization of Tumorigenic Liver Cancer Stem/Progenitor Cells

Stephanie Ma, Kwok‐Wah Chan, Liang Hu et al. · Gastroenterology · 2007 · 1.2K citations · Full text

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Significance of CD90+ Cancer Stem Cells in Human Liver Cancer

Zhen Yang, David Ho, Michael Ng et al. · Cancer Cell · 2008 · 1.2K citations · Full text

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ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation

Laurent Yvan‐Charvet, Tamara A. Pagler, Emmanuel L. Gautier et al. · Science · 2010 · 702 citations · Full text