Concepedia

Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance

Ping Zhang, Harindra E. Amarasinghe, Justin P. Whalley, Chwen Tay, Hai Fang, Gabriele Migliorini, Andrew Brown, Alice Allcock, Giuseppe Scozzafava, Phalguni Rath,

Genome biology · 2022 · 33 citations · 53 references

DOIFull text

Open access

Abstract

Our study demonstrates the importance of context-specific macrophage enhancers in gene regulation and utility for interpreting disease associations, providing a roadmap to link genetic variants with molecular and cellular functions.

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