Concepedia

Phosphorylation on Syk Y342 is important for both ITAM and hemITAM signaling in platelets

John C. Kostyak, Benjamin Mauri, Carol Dangelmaier, Hymavathi Reddy Vari, Akruti Patel, Monica Wright, Haritha Reddy, Alexander Y. Tsygankov, Satya P. Kunapuli

Journal of Biological Chemistry · 2022 · 15 citations · 41 references

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Concepts

Abstract

injury was prolonged in Syk Y342F mice. These data demonstrate that phosphorylation of Y342 on Syk following stimulation of either GPVI or CLEC-2 receptors is important for the ability of Syk to transduce a signal.

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