NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis

Abstract

Primary biliary cholangitis (PBC) is a rare inflammatory condition of the bile ducts. It can be treated with ursodeoxycholic acid, but a large percentage of patients respond poorly to this treatment. Liver-infiltrating memory CD8⁺ T cells recognizing the PDC-E2 immunodominant epitope are critical in the pathogenesis of PBC. We identifed the key pathogenic CD8⁺ T cell subset, and worked out the mechanisms of its hyperactivation and longevity, which could be exploited therapeutically.