Eosinophils protect against acetaminophen‐induced liver injury through cyclooxygenase‐mediated IL‐4/IL‐13 production

Abstract

The current study revealed that eosinophil-derived IL-4/IL-13 accounted for the hepatoprotective effect of eosinophils during AILI. The data demonstrated that the p38 MAPK/COX/NF-κB signaling cascade played a critical role in inducing IL-4/IL-13 production by eosinophils in response to IL-33.