Concepedia

Depletion of Mannose Receptor–Positive Tumor-associated Macrophages via a Peptide-targeted Star-shaped Polyglutamate Inhibits Breast Cancer Progression in Mice

Anni Lepland, Alessio Malfanti, Uku Haljasorg, Eliana K. Asciutto, Mónica Pickholz, Mauro Bringas, Snežana Đorđević, Liis Salumäe, Pärt Peterson, Tambet Teesalu,

Cancer Research Communications · 2022 · 23 citations · 77 references

DOIFull text

Open access

Abstract

A peptide-targeted nanoformulation of DOX exclusively eliminates mannose receptor+ TAMs in breast cancer models, generating response without off-target effects (a drawback of many TAM-depleting agents under clinical study).

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